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Furthermore, inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) each attenuated renal fibroblast proliferation and collagen production, suggesting the mechanistic role for each in mediating the effect of TMAO on renal fibroblast proliferation

Keap1 contains several cysteine residues that function as sensors of oxidative stress and act as negative regulators of Nrf2 [82]

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All reagents were obtained from Sigma-Aldrich unless otherwise indicated

Milks MW, Velez MR, Mehta N, Ishola A, Van Houten T, Yildiz VO, et al